Electrokinetically Altered Normal Saline Modulates Ion Channel Activity

Ultrasound modulates ion channel currents.

Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To test this hypothesis, we expressed potassium and sodium mechanosensitive ion c...

Ion channel activity drives ion channel expression.

Normal saline and mucous plugging.

cialist in the medical critical care/pulmonary unit at Christiana Care Health System in Newark, Delaware. history of smoking along with chronic respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, asthma, and bronchiectasis. Other patient-related factors that may contribute include smoking, immobility, sedation, muscle weakness, and dehydration. A mucous plug occ...

Electrokinetically Actuated Protein Crystallization

Currently, x-ray crystallography is the primary experimental tool employed to understand how proteins fold and assemble into well-defined structures. These diffraction methods critically depend the ability to produce high-purity crystal samples, but conventional crystallization processes are inherently slow and challenging to control. Here we explore a fundamentally different electrokinetically...

Normal Saline vs. Hypertonic Saline Nebulization for Acute Bronchiolitis: A Randomized Clinical Trial

BackgroundWe aimed to compare the efficacy of nebulized hypertonic (3%, 5% and 7%) saline with normal saline in hospitalized infants with acute bronchiolitis.Materials and MethodsIn this triple-blinded randomized clinical trial, 120 children with moderate to severe bronchiolitis randomly assigned into four groups to receive nebulized normal saline (group A),  saline 3% (group B), saline 5% (gro...